Cardiology

Cardiovascular Aging

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Cardiac aging is a heterogeneous process caused by a combination of stochastic events which manifests as loss of structure and function in the heart, however several recent studies draw attention to aging being primarily a stem cell problem. Autophagy, a cellular housekeeping process, is essential to maintain tissue homeostasis, particularly in long-lived cells such as cardiomyocytes. Autophagic activity declines with age and may explain many features of age-related cardiac dysfunction. Impaired autophagic clearance of protein aggregates or deteriorating mitochondria will have multiple consequences including increased arrhythmia risk, decreased contractile function, reduced tolerance to ischemic stress, and increased inflammation; thus autophagy represents a potentially important therapeutic target to mitigate the cardiac consequences of aging. Aging results in progressive deteriorations in the structure and function of the heart and is a dominant risk factor for cardiovascular diseases, the leading cause of death in Western populations.

Related Conferences

7^th World Cardiothoracic Meeting March 29-30, 2016 Atlanta, USA; Echo Cardiography Conference June 06-07, 2016 London, UK; Ischemic Heart Diseases Conference May 12-13, 2016 Chicago, USA; 8^th Global Cardiologists Annual Meeting July 18-20, 2016 Berlin, Germany; Annual Conference on Atherosclerosis July 11-12, 2016 Philadelphia, USA; Drug Discovery and Therapy World Congress May 11-14, 2016, Boston, USA; 7^th International Conference on Drug Discovery and Therapy, February 15-18, 2016 Dubai, UAE; Arrhythmias & the Heart: A Cardiovascular Update, February 12–16, 2016, Riyadh, Saudi Arabia; 16^th Annual International Symposium on Congenital Heart Disease, February 13–16, 2016, St. Petersburg, USA; Cardiovascular Conference at Snowbird, February 12-15, 2016, Snowbird, Utah; Korean Cardiology Related Societies Joint Scientific Congress, April 15-16, 2016, Daegu, Korea.