Regina Celia Spadari
Universidade Federal de Sao Paulo, Brazil
Title: Stress and sirtuins function on beta adrenergic signaling in the heart
Biography
Biography: Regina Celia Spadari
Abstract
Stress affect at least 90% of the world population, as a result of the current lifestyle. In the heart, catecholamines released during the stress response activate beta adrenergic receptors (?-AR), mainly beta
1 (?1-AR) and beta 2 (?2-AR) subtypes. Alterations in the proportion of ?-ARs subtypes, with a role played by ?2-ARs-Gi protein-PI3K-Akt signaling pathways, have been described in several cardiovascular disorders, including heart failure, aging, and in animal models of behavioral stress. This has been the focus of our research group. More recently, it has been shown that sirtuins play a role in several organic processes through the activation of the PI3K-Akt signaling.
Sirtuins are involved in the modulation of the cellular stress response, by activating several downstream molecules, such as those involved in the control of p53, Akt, HIF1-? and NF-?B. SIRT1 and SIRT3 are crucially related to the regulation of cardiomyocyte energy metabolism, production of reactive oxygen species. In the cardiac tissue, SIRT and ?2-ARs-Gi control signaling pathways of cell survival and death, with various roles in the regulation of energy production and oxidative stress, aging, autophagy, energy metabolism, oxidative stress and some diseases. Here, the role played by ?2-ARs and sirtuins during aging, heart fails and in the adaptation to stress is revised and a hypothesis is presented of an interplay between ?2-ARs and sirtuins in the heart.